A 1 SD mmHg increase in office blood pressure, independent of ambulatory blood pressure, predicted cardiovascular events in treated hypertensive patients, in a new subanalysis of the Office versus Ambulatory (OvA) blood pressure study. This analysis was reported by°Dr. DeBuyzere°from the University of Ghent in Belgium at the 15th European Meeting of Hypertension in Milan. The previously reported main results of the OvA study showed that ambulatory blood pressures were prognostic for cardiovascular events, even after adjustment for classic risk factors.
The relative hazard ratio (RHR) for a 1 SD increase in office systolic blood pressure was 1.30 for adjusted 24-hour ambulatory blood pressure (ABP), 1.32 for adjusted daytime ABP, and 1.32 for adjusted nighttime ABP. The RHR for a 1 SD increase in office diastolic blood pressure was 1.31 for adjusted 24-hour ABP, 1.30 for adjusted daytime ABP, and 1.33 for adjusted nighttime ABP.
Other analyses did not show any further predictive value, including short time periods of ABP, isolated uncontrolled office BP compared to fully controlled or fully uncontrolled office and ABP, and systolic and diastolic blood pressures and their respective ABP measurements.